Date of Award

5-2014

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Keith Kyler, Ph.D.

Second Advisor

Jonathan Southard, Ph.D.

Third Advisor

Nathan McElroy, Ph.D.

Fourth Advisor

Carl LeBlond, Ph.D.

Abstract

Oral disease and oral caries is and has for a long time been a significant factor in human health. This research project is aimed at understanding the growth and inhibition of Streptococcus mutans the leading bacterial strain in the human mouth contributing to oral caries and gum disease. S. mutans was grown and tested against three newly designed inhibitors. Syntheses of these inhibitors were done through a simple cost effective method designed with the idea of creating a more affordable prevention method of oral caries. The newly synthesized inhibitors were tested against the bacteria strain S. mutans and the results were quantified. The three inhibitors showed a significant degree of inhibitory action on the growth of S. mutans over a period of 24 hours. These findings indicate that inhibitors 1-3 show a strong potential for being an effective method of oral caries prevention.

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