Date of Award
Master of Science (MS)
Both high fat diets and antihistamines have been implicated in human and animal metabolic disorders. Interaction of these factors is poorly understood. Omega-3 hepatoprotection is under-studied regarding drug-diet interactions. Two murine studies examined high fat versus omega-3 fatty acid diets and fexofenadine administration on metabolic disturbances. Based on run-in period, fexofenadine altered body weights specific to dietary grouping. With longer run-in times, fexofenadine and high-fat diet increased fat pad, liver, and body weights, while omega-3 body weights matched control. In contrast, shorter run-in times resulted in body weight decreases in high fat and omega-3-fed fexofenadine-treated mice, as well as increased fat pad masses and reduced serum glucose concentrations. Fexofenadine administration appears to affect body weight dependent on dietary fat and pre-drug run-in periods. Stress-induced biological factors may play a role in acclimation of mice to study conditions.
Smith, Elisabeth C., "Effects of the Antihistamine Fexofenadine on Body Fat, Glucose and Body Weight: Impact of Dietary Fat Type and Pre-Drug Run-in Period" (2017). Theses and Dissertations (All). 1470.