Date of Award
5-2014
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Keith Kyler, Ph.D.
Second Advisor
Jonathan Southard, Ph.D.
Third Advisor
Nathan McElroy, Ph.D.
Fourth Advisor
Carl LeBlond, Ph.D.
Abstract
Oral disease and oral caries is and has for a long time been a significant factor in human health. This research project is aimed at understanding the growth and inhibition of Streptococcus mutans the leading bacterial strain in the human mouth contributing to oral caries and gum disease. S. mutans was grown and tested against three newly designed inhibitors. Syntheses of these inhibitors were done through a simple cost effective method designed with the idea of creating a more affordable prevention method of oral caries. The newly synthesized inhibitors were tested against the bacteria strain S. mutans and the results were quantified. The three inhibitors showed a significant degree of inhibitory action on the growth of S. mutans over a period of 24 hours. These findings indicate that inhibitors 1-3 show a strong potential for being an effective method of oral caries prevention.
Recommended Citation
Hummel, Michael Christensen, "Development of Novel Compounds for the Inhibition of Tooth and Gum Bacteria" (2014). Theses and Dissertations (All). 1138.
https://knowledge.library.iup.edu/etd/1138