Synthesis of Non-Toxic Compounds and the Inhibition of Oral Bacteria

Monica Bhupendra Patel, Indiana University of Pennsylvania


In recent years, research has shown that dental care correlates with many health factors due to the amount of bacteria present in the mouth. Thus, it is important to create more efficient compounds to fight oral bacteria, specifically Streptococci mutans. This research chose cost effective compounds to inhibit the cavity causing S. mutans. Based on a study on phenolic antibacterial compounds against oral bacteria, 4- hexylphenol had reasonable germ-kill activity and log P values. By modeling this compound with one alcohol group and a long hydrophobic carbon chain, Geraniol was chosen as a starting material. Three compounds were synthesized and confirmed through 1Hydrogen Nuclear Magnetic Resonance spectroscopy. All three compounds showed over 50% inhibition of Streptococci mutans within a 24-hr period when comparing Colony Forming Units/mL.