Date of Award
Spring 5-2017
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Keith Kyler, Ph.D.
Second Advisor
Jonathan Southard, Ph.D.
Third Advisor
Nathan McElroy, Ph.D.
Fourth Advisor
Avijita Jain, Ph.D.
Abstract
In recent years, research has shown that dental care correlates with many health factors due to the amount of bacteria present in the mouth. Thus, it is important to create more efficient compounds to fight oral bacteria, specifically Streptococci mutans. This research chose cost effective compounds to inhibit the cavity causing S. mutans.
Based on a study on phenolic antibacterial compounds against oral bacteria, 4- hexylphenol had reasonable germ-kill activity and log P values. By modeling this compound with one alcohol group and a long hydrophobic carbon chain, Geraniol was chosen as a starting material.
Three compounds were synthesized and confirmed through 1Hydrogen Nuclear Magnetic Resonance spectroscopy. All three compounds showed over 50% inhibition of Streptococci mutans within a 24-hr period when comparing Colony Forming Units/mL.
Recommended Citation
Patel, Monica, "Synthesis of Non-Toxic Compounds and the Inhibition of Oral Bacteria" (2017). Theses and Dissertations (All). 1429.
https://knowledge.library.iup.edu/etd/1429