Author

Andrew Vitz

Date of Award

12-2018

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biology

First Advisor

Daniel Widzowski

Second Advisor

Christina Ruby

Third Advisor

Robert Hinrichsen

Abstract

The low success rate of the current treatment program and recent success of 5-HT2C modulators in methamphetamine (METH) dependence represented a need for further research on pharmacotherapeutic agents for METH addiction. The research focused on the involvement of the 5-HT2C receptor in METH-induced drug sensitization (DS) and conditioned place preference (CPP) drug-seeking behavior. The video collect from the experiments was analyzed by the EthoVision XT computer program to produce locomotor activation (LMA) data. Investigation of LMA data determined that 2 to 4 month old C57BL/6J mice were ideal for the study. The DS experiment found 3.0 mg/kg of lorcaserin produced a significant, F(3,32) = 31.8, p = .005, reduction in METH-induced sensitization and identified the drug as a possible therapeutic agent. The CPP experimental results suggested further development of the testing protocol was required before a conclusion could be made on the effect of the 5-HT2C receptor in drug-seeking behavior.

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