Date of Award
Master of Science (MS)
The low success rate of the current treatment program and recent success of 5-HT2C modulators in methamphetamine (METH) dependence represented a need for further research on pharmacotherapeutic agents for METH addiction. The research focused on the involvement of the 5-HT2C receptor in METH-induced drug sensitization (DS) and conditioned place preference (CPP) drug-seeking behavior. The video collect from the experiments was analyzed by the EthoVision XT computer program to produce locomotor activation (LMA) data. Investigation of LMA data determined that 2 to 4 month old C57BL/6J mice were ideal for the study. The DS experiment found 3.0 mg/kg of lorcaserin produced a significant, F(3,32) = 31.8, p = .005, reduction in METH-induced sensitization and identified the drug as a possible therapeutic agent. The CPP experimental results suggested further development of the testing protocol was required before a conclusion could be made on the effect of the 5-HT2C receptor in drug-seeking behavior.
Vitz, Andrew, "The Effects of 5-HT2C Receptor Inverse Agonist, Agonist, and Antagonist on Methamphetamine-Induced Behavioral Sensitization and Reinstatement of Drug-Seeking Behavior in Mice" (2018). Theses and Dissertations (All). 1671.